Key findings
The ArgoCap allowed for good visibility, a precise and constant application of the argon beam, and a constant distance to the mucosa
APC with ArgoCap could reach all quadrants of the esophagus ex vivo and in vivo
Treatment of the mucosa was possible ex vivo and in vivo in all investigated modes and power settings
No lesions of the muscular layer or deeper occurred in Precise mode (E8, E9) as well as Forced mode (10W, 20W), whereas Pulsed mode resulted in deep thermal damage in all power settings, indicating that it is not the appropriate mode for use with the ArgoCap
The ArgoCap has the potential to improve APC treatment of larger mucosal areas
Study details
20 porcine esophagi were marked with an area of 1.5 x 1.5 cm with an HF probe. All areas could be reached with the ArgoCap.
132 APC treatments of predefined areas were performed ex vivo followed by histological examination for thermal damage
Used settings: Precise mode (n=51), Pulsed mode (n=51) and Forced mode (n=30)
Lesions of the muscular layer or deeper in the porcine esophagus: Precise mode (n=2; 4%), Forced mode (n=1; 10%), Pulsed mode (n=21; 41%)
Results were transferred and confirmed in a first in vivo application
Mueller J, Kayser G, Kuellmer A, Schiemer M, Dominik B, Offensperger F, Thimme R, Schmidt A. ArgoCap – feasibility and safety of a novel over-the-scope device to facilitate endoscopic APC treatment. Minim Invasive Ther Allied Technol. 2023;32(3):103-11. doi: 10.1080/13645706.2023.2180322.
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